Why people become addicted – deltaFosB


By David Joel Miller, MS, Licensed Therapist & Licensed Counselor.

Addiction.
Photo courtesy of Pixabay

Is there really something different in the brains of addicted people?

Yes, there really does seem to be a physical change in the brain that accounts for why some people become addicted to chemicals, drugs in particular, and behaviors also. These brain changes may explain why and how people move from just experimenting, trying new novel exciting things, to the point of being addicted. Once addicted, the brain begins to demand more of the chemical or the behavior it has become dependent on.

One possible explanation for this brain change is deltaFosB.

It was quite by accident that I came across a description of deltaFosB and how it was causing a behavioral addiction. That instance had nothing to do with drugs, alcohol, or chemical dependency but came from the field of research on erectile dysfunction.

Erectile dysfunction was once considered purely a problem among older men and presumably their partners. Recently we have discovered there is a group of men who are developing erectile dysfunction at an amazingly young age.

The common denominator in this early onset of erectile dysfunction? Watching pornography. A few views appear to be no problem but those who watch a lot gradually develop a dependency on the watching of porn and become unable to be aroused by a real physical partner. The brain has rewired itself to become dependent on or addicted to porn to achieve sexual arousal.

For more on this see: Your Brain on Porn.

For those of you who like to watch – there is a YouTube TEDx Talks video on this research titled The Great Porn Experiment.

These brain changes do not happen suddenly but a little at a time.

Research on cocaine, morphine, nicotine, ethanol (drinkable alcohol), and Delta (9)-tetrahydrocannabinol (Delta (9)-THC, the active ingredient in marijuana, found they all produce specific changes in the brain. These changes do not happen suddenly from one dose but gradually over time the levels of deltaFosB increase and at some point, different for different people or different for different mice, and the brain begins to rewire itself to depend on the drug.  Interestingly enough each drug changes the brain in a different characteristic way.

Patterns of addiction to different drugs involve different changes in the brain. For more on this see: Distinct Patterns of ΔFosB Induction in Brain by Drugs of Abuse by Perrotti LI, Et. Al. Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas.

A full explanation of the chemistry involved is beyond my expertise or the scope of this blog but I have included a few links to some resources on the topic for those of you who are so inclined.

Wikipedia describes the role of deltaFosB this way.

“The ΔFosB splice variant has been identified as playing a central, crucial (necessary and sufficient) role in the development of many forms of behavioral plasticity and neuroplasticity involved in both behavioral addictions (associated with natural rewards) and drug addictions.”

How many doses does it take to become addicted – Gene Expression.

Genes are a lot more complicated than we used to think. When I went to school back in the post dark-ages era, we thought genes were yes or no things. You inherit your gene for eye color, hair color, height, and so on from your parents in a predictable, dominant-recessive way. Right?

Not really.

There is a thing called gene expression.

My gene for hair color dictated dark black hair. At least in my teens, it did. Those of you who have seen my blog bio picture realize that most of my hair is now gray, Ok maybe we should call it white. How did the gene for my hair color change?

As we age, or under the influence of environment and substances our genes can “Flip.” That switch in our genes moves and now that gene for black hair becomes the gene for white. The same thing happens for behaviors and drugs.

That chemical that used to be just an extra add-on for your pleasure becomes something you must have just to feel passable.

Here is a specific study on the process for those who take cocaine.

Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine.

Now we have an explanation, of sorts, for how someone can use a substance or do a behavior for a while with no problem and then at some point the switch flips and they are now addicted to that drug or behavior. Presumably, this would also allow us to determine which behaviors fit the model as true behavioral addictions and which are just bad habits.

Can we flip that switch back? So far we have not found a way to turn an addict or an alcoholic back into a non-addicted person. You can dye your hair or you can let it go but once you turn gray you are stuck.

Be careful with the behaviors you practice and the chemical you use. They may be changing your brain.

Staying connected with David Joel Miller

Seven David Joel Miller Books are available now!

My newest book is now available. It was my opportunity to try on a new genre. I’ve been working on this book for several years, but now seem like the right time to publish it.

Story Bureau.

Story Bureau is a thrilling Dystopian Post-Apocalyptic adventure in the Surviving the Apocalypse series.

Baldwin struggles to survive life in a post-apocalyptic world where the government controls everything.

As society collapses and his family gets plunged into poverty, Baldwin takes a job in the capital city, working for a government agency called the Story Bureau. He discovers the Story Bureau is not a benign news outlet but a sinister government plot to manipulate society.

Bumps on the Road of Life. Whether you struggle with anxiety, depression, low motivation, or addiction, you can recover. Bumps on the Road of Life is the story of how people get off track and how to get your life out of the ditch.

Dark Family Secrets: Doris wants to get her life back, but small-town prejudice could shatter her dreams.

Casino Robbery Arthur Mitchell escapes the trauma of watching his girlfriend die. But the killers know he’s a witness and want him dead.

Planned Accidents  The second Arthur Mitchell and Plutus mystery.

Letters from the Dead: The third in the Arthur Mitchell mystery series.

What would you do if you found a letter to a detective describing a crime and you knew the writer and detective were dead, and you could be next?

Sasquatch. Three things about us, you should know. One, we have seen the past. Two, we’re trapped there. Three, I don’t know if we’ll ever get back to our own time.

For these and my upcoming books; please visit my Author Page – David Joel Miller

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For videos, see: Counselorssoapbox YouTube Video Channel

2 thoughts on “Why people become addicted – deltaFosB

  1. Pingback: Is watching porn causing your relationship problems? | counselorssoapbox

  2. Pingback: Is addiction real? Does it have a cause? | counselorssoapbox

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